N-((1S,3R)-3-(allyloxy)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl)-2,2,2-trifluoroacetamide → (1S,3R)-3-(allyloxy)-4,6-dimethyl-2,3-dihydro-1H-inden-1-amine

Participants

Reaction Steps

Step BN (1): N-((1S,3R)-3-(allyloxy)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl)-2,2,2-trifluoroacetamide from Preparation BM was N-deprotected by a procedure analogous to Step U (2) to afford 900 mg (94% yield) of (1S,3R)-3-(allyloxy)-4,6-dimethyl-2,3-dihydro-1H-inden-1-amine as a white solid. LC-MS (M+H)+=218.15; 1H NMR (500 MHz, CDCl3) δ ppm 7.00 (s, 1H) 6.90 (s, 1H) 5.91-6.04 (m, 1H) 5.26-5.34 (m, 1H) 5.13-5.20 (m, J=10.38, 1.53 Hz, 1H) 4.18-4.05 (m, 2H) 4.05-4.00 (m, 1H) 2.57-2.67 (m, 1H) 2.34 (s, 3H) 2.32 (s, 3H) 1.80-1.92 (m, 4H).

Provenance & Evidence