Di-3-pyridinylmethanone → [4-(3-Ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanol

HRID 50176Notes

Reaction equation

HRID 50176 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][CH3:22])[CH:15]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([C:31]2[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=2)=[O:30])[CH:24]=1>>[CH2:21]([O:20][C:16]1[CH:15]=[C:14]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([C:29]([C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)([C:25]4[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=4)[OH:30])[CH:3]=3)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=2)[CH:19]=[CH:18][CH:17]=1)[CH3:22]

Participants

3

Reactant 2

HCID 298471Di-3-pyridinylmethanoneHCID 224654196-Bromo4-(3-ethoxy-phenyl)-2-methoxy-quinoline

Product 1

HCID 22465390[4-(3-Ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-di-pyridin-3-yl-methanolYield 41.2%

Procedure

Following the same procedure as that described in example 1E, 6-bromo-4-(3-ethoxy-phenyl)-2-methoxy-quinoline (400 mg, 1.11 mmol) and di-pyridin-3-yl-methanone (225 mg, 1.22 mmol) generated the title compound of 37A (212 mg, 41.2% yield).

Sources & evidence

ORD record
ord-92ff14d55bef43148911363873a59fd9
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

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