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HRID501763

反应详情

EQUATION

反应方程式

HRID 501763 的结构方程式

REACTANTS

反应物

3
结构：C=CCCCC(=O)O
HCID15308

5-Hexenoic acid

C6H10O2

结构：C=CCO[C@@H]1C[C@H](NC[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](N)CC(C)C)c2cc(OC(C)C)ccc21
HCID59423736

未命名化合物

结构：C=CCO[C@@H]1C[C@H](NC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c2cc(Br)ccc21
HCID68465135

未命名化合物

2 次

PRODUCTS

生成物

1
结构：C=CCCCC(=O)N[C@@H](CC(C)C)[C@@H](CN[C@H]1C[C@@H](OCC=C)c2ccc(OC(C)C)cc21)O[Si](C)(C)C(C)(C)C
HCID68463755

未命名化合物

PROCEDURE

实验过程

Step EQ (1): Hex-5-enoic acid (240 mg, 2.1 mmol) and (2R,3S)-N1-((1S,3R)-3-(allyloxy)-6-isopropoxy-2,3-dihydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)-5-methylhexane-1,3-diamine (1.1 g, 2.2 mmol, from Preparation BH) were coupled using a procedure analogous to Step CA (1) to afford N-((2R,3S)-1-((1S,3R)-3-(allyloxy)-6-isopropoxy-2,3-dihydro-1H-inden-1-ylamino)-2-(tert-butyldimethylsilyloxy)-5-methylhexan-3-yl)hex-5-enamide. LC-MS (M+H)+=587.47.