Hydrochloric Acid → HCID 23021517, compound

Participants

Reaction Conditions

Reaction Steps

0.770 g of 4-cyclopentyl-2-hydroxybenzaldehyde, 0.38 mL of iodomethane, and 0.839 g of potassium carbonate were suspended in 7.7 mL of N,N-dimethylformamide, and this mixture was stirred for 2 hours at 75° C. The reaction mixture, which was cooled to room temperature, was added to a mixture of ethyl acetate and water, and then adjusted to pH 3 with 6M hydrochloric acid, and the organic phase was separated therefrom. After the resultant organic phase was washed with water and a saturated sodium chloride solution successively, the washed phase was dried over anhydrous magnesium sulfate, and the solvent was distilled out under reduced pressure to yield 0.777 g of 4-cyclopentyl-2-methoxybenzaldehyde as yellow oil.

Provenance & Evidence