6-Bromo-4-(3-chlorophenyl)-2-methoxyquinoline → HCID 22465409, compound

HRID 50183Notes

Reaction equation

HRID 50183 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1.[S:21]1[C:25]([C:26]([C:28]2[N:29]([CH3:33])[CH:30]=[N:31][CH:32]=2)=[O:27])=[CH:24][C:23]2[CH:34]=[CH:35][CH:36]=[CH:37][C:22]1=2>>[S:21]1[C:25]([C:26]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=[C:5]3[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)([C:28]2[N:29]([CH3:33])[CH:30]=[N:31][CH:32]=2)[OH:27])=[CH:24][C:23]2[CH:34]=[CH:35][CH:36]=[CH:37][C:22]1=2

Participants

3

Reactant 2

HCID 120166726-Bromo-4-(3-chlorophenyl)-2-methoxyquinolineHCID 22465420HCID 22465420, compound

Product 1

HCID 22465409HCID 22465409, compoundYield 62%

Procedure

Following the same procedure as described in example 1E, 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline (273 mg, 0.784 mmol) and benzo[b]thiophen-2-yl-(3-methyl-3H-imidazol-4-yl)-methanone (247 mg, 1.01 mmol) generated the title compound of 41A (248 mg, 62% yield).

Sources & evidence

ORD record
ord-60b4221398714d0884b52a1e38bc88c7
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

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