2-(4-Acetylamino-phenoxy)-propionic acid methyl ester → 2-(4-Aminophenoxy)propanoic acid

Participants

Reaction Conditions

Reaction Steps

2-(4-Acetylaminophenoxy)-propionic acid methyl ester 8 (320 g, 1.35 mol) in conc. HCl (8 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 9 (240 g, 81.7%) as a brown powder with an m.p between 175-180° C.

Provenance & Evidence