Hydrochloric Acid → 6-[Benzo[b]thiophen-2-yl-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1h-quinolin-2-one

Participants

Reaction Steps

Following the same procedure as described in example 1F, benzo[b]thiophen-2-yl-[4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (147.2 mg, 0.287 mmol) was treated with HCl in aqueous THF to yield the title compound of 41B as a yellow solid (40 mg, 28% yield).

Provenance & Evidence