Dichloromethane → Eszopiclone

Participants

Reaction Steps

45 ml of dichloromethane were added to a solution of 3 g of (S)-zopiclone N-acetyl-L-aspartate in 6 ml of water at room temperature. The mixture is basified to pH 10 with a solution of 40% aqueous potassium carbonate. The aqueous layer is decanted and extracted with 45 ml of dichloromethane. Organic layers were joined together and concentrated under vacuum until dryness obtaining 2.04 g of eszopiclone (100%) as a white solid.

Provenance & Evidence