反应详情

tert-Butyl 4-hydroxy-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate (300 mg, 0.87 mmol) was dissolved in trifluoroacetic acid (50% in dichloromethane, 6 mL). The reaction was stirred 30 min and concentrated. The residue was dissolved in water, extracted with dichloromethane (2×) which were discarded. The aqueous was made basic with solid potassium carbonate. The resulting solid was filtered to give 145 mg (68%) as a white powder. Mass spec.: 245.35 (MH)+.

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in water
3. extractionextracted with dichloromethane (2×) which
4. filtrationThe resulting solid was filtered
5. customto give 145 mg (68%) as a white powder