反应详情

To a solution of (R)-1-methoxy-3-(2-(methoxymethyl)-7-methyl-2H-indazol-5-yl)-1-oxopropan-2-yl 4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate (1.20 g, 2.25 mmol) in methanol (20 mL) was added acetyl chloride (0.40 mL, 5.62 mmol). The reaction was warmed to reflux and held there for 1 h. The reaction was concentrated by rotary evaporation under high vacuum and purified by column chromatography (5% methanol/dichloromethane) to give 1.09 g (99%) as a white foam solid. Mass spec.: 489.29 (MH)+.

1. temperatureThe reaction was warmed
2. temperatureto reflux
3. concentrationThe reaction was concentrated by rotary evaporation under high vacuum
4. custompurified by column chromatography (5% methanol/dichloromethane)
5. customto give 1.09 g (99%) as a white foam solid