HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Amidinophenylethyl]-3-methyl-6-(2-methoxycarbonyl-2.3-dihydroindol-1-yl-carbonyl) imidazo[4.5-b]pyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | 2-[2-(4-Cyanophenyl)ethyl]-3-methyl-6-(2-methoxycarbonyl-2,3-dihydroindol-1-yl-carbonyl)-imidazo[4,5-b]pyridine | HCID 18412512 | — |
| Reactant | Ethyl acetate ethanol ammonia | HCID 86587043 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Amidinophenylethyl]-3-methyl-6-(2-methoxycarbonyl-2.3-dihydroindol-1-yl-carbonyl) imidazo[4.5-b]pyridine hydrochloride | HCID 18412357 | 20% |
Reaction Steps
Prepared analogously to Example 1 from 2-[2-(4-cyanophenyl)ethyl]-3-methyl-6-(2-methoxycarbonyl-2,3-dihydroindol-1-yl-carbonyl)imidazo[4,5-b]pyridine, methanolic hydrochloric acid, methanol, and ammonium carbonate. Yield: 20% of theory, C27H26N6O3 (482.54); Rf value: 0.30 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=483.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-b6e4f9dce14c45c49596fa618965b7d5 |
| Source note | uspto-grants-2004_03 |