HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-[2-(4-Amidinophenyl)ethyl]-3-methyl-6-(2-carboxy-2,3-dihydroindol-1-yl-carbonyl)-imidazo[4,5-b]pyridine-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(4-Amidinophenylethyl]-3-methyl-6-(2-methoxycarbonyl-2.3-dihydroindol-1-yl-carbonyl) imidazo[4.5-b]pyridine hydrochloride | HCID 18412357 | — |
| Reactant | Ethyl acetate ethanol ammonia | HCID 86587043 | — |
| Product | 2-[2-(4-Amidinophenyl)ethyl]-3-methyl-6-(2-carboxy-2,3-dihydroindol-1-yl-carbonyl)-imidazo[4,5-b]pyridine-hydrochloride | HCID 18412659 | 90% |
Reaction Steps
Prepared analogously to Example 2 from 2-[2-(4-amidinophenyl)ethyl]-3-methyl-6-(2-methoxycarbonyl-2,3-dihydroindol-1-yl-carbonyl)imidazo[4,5-b]pyridine hydrochloride and sodium hydroxide solution. Yield: 90% of theory, C26H24N6O3 (468.52); Rf value: 0.24 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=469; (M+Na)+=491.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-fe5b0b0228cc4c038b08de92e024fca2 |
| Source note | uspto-grants-2004_03 |