HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502013Generated: November 2, 2026
Hydrochloric Acid → Sertraline Hydrochloride
https://huagongshe.com/reaction/502013
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isoamyl Alcohol | HCID 31260 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Isoamyl alcohol (30 ml) and ethyl acetate (30 ml) are added to sertraline free base (10 gm) under stirring at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25-30° C. and then stirred for 4 hours 15 minutes at 25-30° C. Filtered the solid and dried for 7 hours at 60° C. to give 7.4 gm of sertraline hydrochloride crystalline form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07772437B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-cc7411147b894679bad9b3d17156adeb |
|---|
| Source note | uspto-grants-2010_08 |
|---|
