HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502016Generated: October 29, 2026
Hydrochloric Acid → Sertraline Hydrochloride
https://huagongshe.com/reaction/502016
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
| Solvent | 2-Methyl-2-butanol | HCID 6405 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Sertraline mandelate (10 gm) is suspended in tert-amyl alcohol (65 ml) at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25-30° C. and then stirred for 8 hours at 25-30° C. Filtered the solid and dried at 60° C. for 3 hours 30 minutes to give 4.3 gm of sertraline hydrochloride crystalline form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07772437B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-7122467702b94d5ba30e3de22736d8a7 |
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| Source note | uspto-grants-2010_08 |
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