Hydrochloric Acid → Sertraline Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Sertraline free base (10 gm) is dissolved in isoamyl alcohol (70 ml) at 25-30° C., pH of the mass is adjusted to 2.0 by passing hydrogen chloride gas at 2-4° C., raised the mass temperature to 30° C. during 2 hours and then stirred for 4 hours at 25-30° C. Filtered the solid and dried for 7 hours at 60° C. to give 7.2 gm of sertraline hydrochloride crystalline form II.

Provenance & Evidence