HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502021Generated: October 30, 2026
Hydrochloric Acid → Sertraline Hydrochloride
https://huagongshe.com/reaction/502021
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sertraline | HCID 68617 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | — |
Reaction Steps
Sertraline free base (10 gm) is dissolved in isoamyl alcohol (70 ml) at 25-30° C., pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 10-15° C., raised the mass temperature to 25° C. during 30 minutes and then stirred for 3 hours 30 minutes at 25-30° C. Filtered the solid and dried for 7 hours at 60° C. to give 5.4 gm of sertraline hydrochloride crystalline form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07772438B2 |
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| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-edc06f28b37a48c89a7d66df604bcf80 |
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| Source note | uspto-grants-2010_08 |
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