1-Hydroxybenzotriazole → N-[2-(4-chlorophenoxy)ethyl]-3-(3,4-dimethoxybenzamido)-4-methylbenzamide

https://huagongshe.com/reaction/502033

참여 물질

역할	이름	HCID	투입량
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
반응물	2-(4-Chlorophenoxy)ethylamine	HCID 2794191	—
반응물	3-[(3,4-Dimethoxybenzoyl)amino]-4-methylbenzoic acid	HCID 3600179	—
촉매	4-(Dimethylamino)pyridine	HCID 14284	—
용매	Dichloromethane	HCID 6344	—
생성물	N-[2-(4-chlorophenoxy)ethyl]-3-(3,4-dimethoxybenzamido)-4-methylbenzamide	HCID 22636102	67.7%

반응 단계

A solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.095 g) in methylene chloride (5 ml) was added to a stirred mixture of 3-(3,4-dimethoxybenzamido)-4-methylbenzoic acid (0.157 g), 2-(4-chlorophenoxy)ethylamine (C. Chim. Ther., 1973, 8, 259; 0.086 g), 4-dimethylaminopyridine (0.007 g), 1-hydroxybenzotriazole (0.074 g) and methylene chloride (5 ml). The resultant mixture was stirred at ambient temperature for 16 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and a saturated aqueous sodium bicarbonate solution. The organic phase was washed with an aqueous citric acid solution, dried over magnesium sulphate and evaporated. There was thus obtained the title compound as a solid (0.158 g); Mass Spectrum: M+H+ 469.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07772432B2
출처 데이터셋	uspto-grants-2010_08
ORD ID	ord-d534d7fcd7fa4f299534f054646de1cd
출처 메모	uspto-grants-2010_08