6-Chloronicotinoyl Chloride → 3-(6-chloropyrid-3-ylcarbonylamino)-N-(3-dimethylaminophenyl)-4-methylbenzamide

HRID 502040Notes

Reaction equation

HRID 502040 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](Cl)=[O:9])=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:13]=[C:14]([CH:27]=[CH:28][C:29]=1[CH3:30])[C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([N:24]([CH3:26])[CH3:25])[CH:19]=1)=[O:16]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:11][C:12]2[CH:13]=[C:14]([CH:27]=[CH:28][C:29]=2[CH3:30])[C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N:24]([CH3:26])[CH3:25])[CH:19]=2)=[O:16])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27821656-Chloronicotinoyl ChlorideHCID 226361113-amino-N-(3-dimethylaminophenyl)-4-methylbenzamide

Product 1

HCID 226361513-(6-chloropyrid-3-ylcarbonylamino)-N-(3-dimethylaminophenyl)-4-methylbenzamide

Procedure

Using an analogous procedure to that described in Example 1, 6-chloropyrid-3-ylcarbonyl chloride was reacted with 3-amino-N-(3-dimethylaminophenyl)-4-methylbenzamide to give the title compound; Mass Spectrum: M+H+ 409 and 411.

Sources & evidence

ORD record
ord-fd0f2cf70375479eb831f45262ce1471
Source dataset
uspto-grants-2010_08
Patent number
US07772432B2

Reaction notes

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