Methanol → HCID 57763473, compound

Participants

Reaction Steps

A mixture of methyl (4-{1-ethyl-1-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]propyl}-2-methylbenzoylamino)acetate (0.43 g, 0.89 mmol), CH3OH (10 ml), NaOH (0.18 g, 4.46 mmol), and H2O (1 mL) is refluxed for 2 h. The reaction is concentrated, diluted with H2O (5 ml), acidified (pH 3-4) with 0.1 M HCl and extracted with EtOAc (3×15 mL). The combined organic layers are MgSO4 dried, and concentrated to give the title compound (0.29 g, 71%).

Provenance & Evidence