反应详情

温度

-78 °C

33.8 ml of a 1.6 M solution of n-butyllithium in hexane are added dropwise under argon to a solution of 17.4 g 1-bromo-4-triisopropylsilylethynyl-benzene in 120 ml dry tetrahydrofuran chilled to −78° C. The solution is stirred for 1 h at −70° C. Then 10.8 g 5-bromo-2-fluoro-benzaldehyde dissolved in 30 ml of tetrahydrofuran are added dropwise over 15 min. The resulting solution is left in the cooling bath to warm up overnight to ambient temperature. Then water is added and the mixture is extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate, and the solvent is removed. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 4:1).

1. additionare added dropwise over 15 min
2. waitThe resulting solution is left in the cooling bath
3. temperatureto warm up overnight to ambient temperature
4. extractionthe mixture is extracted with ethyl acetate
5. dry with materialThe combined organic phases are dried over sodium sulfate
6. customthe solvent is removed
7. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 4:1)