Ethyl isocyanate → HCID 59425237, compound

HRID 502208Notes

Reaction equation

HRID 502208 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:22]#[N:23])=[C:7]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH3:21])=[CH:15][CH:14]=3)[N:8]2[CH2:11][CH3:12])=[CH:4][CH:3]=1.[CH2:24]([N:26]=[C:27]=[O:28])[CH3:25]>ClCCl>[C:22]([C:6]1[C:5]2[C:9](=[CH:10][C:2]([NH:1][C:27]([NH:26][CH2:24][CH3:25])=[O:28])=[CH:3][CH:4]=2)[N:8]([CH2:11][CH3:12])[C:7]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH3:21])=[CH:15][CH:14]=1)#[N:23]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 59425167HCID 59425167, compound

Product 1

HCID 59425237HCID 59425237, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-Amino-2-(4-ethoxyphenyl)-1-ethyl-1H-indole-3-carbonitrile (31 mg, 0.1 mmol) is treated with ethyl isocyanate (14 mg, 0.2 mmol) in dichloromethane (1.0 mL) at 40° C. overnight. The precipitate is collected via filtration, washed with dichloromethane and dried in air to furnish 1-[3-cyano-2-(4-ethoxy-phenyl)-1-ethyl-1H-indol-6-yl]-3-ethyl-urea (36 mg, 95%).

Workup

  1. filtrationThe precipitate is collected via filtration
  2. washwashed with dichloromethane
  3. customdried in air

Sources & evidence

ORD record
ord-689dad4ae11d4c428b2ae7e0e2baddb8
Source dataset
uspto-grants-2010_08
Patent number
US07772271B2

Reaction notes

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