Sodium Hydroxide → HCID 18412374, compound

HRID 50226Notes

Reaction equation

HRID 50226 reaction equation
[ClH:1].[CH2:2]([N:5]([CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])[C:6]([C:8]1[CH:9]=[CH:10][C:11]2[S:15][C:14]([CH2:16][NH:17][C:18]3[CH:23]=[CH:22][C:21]([C:24](=[NH:26])[NH2:25])=[CH:20][CH:19]=3)=[N:13][C:12]=2[CH:27]=1)=[O:7])[CH2:3][CH3:4].[OH-].[Na+]>C(O)(=O)C.C(Cl)Cl.C(O)C>[ClH:1].[CH2:2]([N:5]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C:6]([C:8]1[CH:9]=[CH:10][C:11]2[S:15][C:14]([CH2:16][NH:17][C:18]3[CH:23]=[CH:22][C:21]([C:24](=[NH:25])[NH2:26])=[CH:20][CH:19]=3)=[N:13][C:12]=2[CH:27]=1)=[O:7])[CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 18412321HCID 18412321, compound

Product 1

HCID 18412374HCID 18412374, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 10 from 2-[N-(4-amidinophenyl)aminomethyl]benzothiazol-5-yl-carboxylic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 75% of theory, C22H25N5O3S (439.54); Rf value: 0.14 (silica gel; methylene chloride/ethanol=4:1+a few drops of acetic acid); EKA mass spectrum: (M+H)+=440; (M+H+Na)++=231.6.

Sources & evidence

ORD record
ord-a43214c2eb2844da9e095083daddc9bd
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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