反应详情

1.6 g (4.3 mmol) of 4-methylamino-3-chloracetamidobenzoic acid-N-(n-propyl)-N-(2-ethoxycarbonylethyl)amide were heated to 100° C. in 25 mL of acetic acid for 30 minutes. Then the solvent was distilled off, the crude product was taken up in 40 mL methylene chloride/ethanol (9:1) and washed with 20 mL saturated sodium hydrogen carbonate solution. The organic phase was dried with sodium sulfate and evaporated down. Yield: 1.5 g (100% of theory) of brown oil; Rf value: 0.63 (silica gel; ethyl acetate/ethanol/ammonia=90:10:1).

1. distillationThen the solvent was distilled off
2. washwashed with 20 mL saturated sodium hydrogen carbonate solution
3. dry with materialThe organic phase was dried with sodium sulfate
4. customevaporated down