HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-2-[(4-amidinophenyl)thiomethyl]-benzimidazol-5-yl-carboxylic acid-n-(2-methylpropyl)-n-(2-ethoxycarbonylethyl)-amide-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | Ethyl acetate ethanol ammonia | HCID 86587043 | — |
| Reactant | 1-Methyl-2-[(4-cyanophenyl)thiomethyl]-benzimidazol-5-yl-carboxylic acid | HCID 86755517 | — |
| Reactant | 2-methylpropyl-N-(2-ethoxycarbonylethyl)amide | HCID 86755518 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Methyl-2-[(4-amidinophenyl)thiomethyl]-benzimidazol-5-yl-carboxylic acid-n-(2-methylpropyl)-n-(2-ethoxycarbonylethyl)-amide-hydrochloride | HCID 18412463 | 83% |
Reaction Steps
Prepared analogously to Example 27 from 1-methyl-2-[(4-cyanophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-(N-(2-methylpropyl-N-(2-ethoxycarbonylethyl)amide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 83% of theory, C25H31N6O3S (495.65); Rf value: 0.30 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=496.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3b0b20561226416d8d6b8cbe908ff7f6 |
| Source note | uspto-grants-2004_03 |