Indole-4-carboxylic acid → HCID 68456851, compound

HRID 502333Notes

Reaction equation

HRID 502333 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[NH:19]1[C:27]2[CH:26]=[CH:25][CH:24]=[C:23]([C:28](O)=[O:29])[C:22]=2[CH:21]=[CH:20]1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:28]([C:23]3[C:22]4[CH:21]=[CH:20][NH:19][C:27]=4[CH:26]=[CH:25][CH:24]=3)=[O:29])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 595229Indole-4-carboxylic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68456851HCID 68456851, compoundYield 32%

Procedure

The title compound (13 mg, 32%) was prepared analogously to example 1 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with indole-4-carboxylic acid. MS: 412.4 (MH+)

Sources & evidence

ORD record
ord-75b0c34252d74fef8744b1cd18468295
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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