6-(Dimethylamino)-3-pyridinecarboxylic acid → HCID 68458373, compound

HRID 502335Notes

Reaction equation

HRID 502335 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][N:20]([CH3:30])[C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][N:22]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][C:21]([N:20]([CH3:19])[CH3:30])=[N:22][CH:23]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 992096-(Dimethylamino)-3-pyridinecarboxylic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68458373HCID 68458373, compoundYield 26%

Procedure

The title compound (11 mg, 26%) was prepared analogously to example 1 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 6-dimethylamino nicotinic acid (J. Org. Chem. 1999, 9, 2293). MS: 417.4 (MH+)

Sources & evidence

ORD record
ord-507cce4fcfbd45ab99aa8b462e4b2c73
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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