3-Methylbenzoyl chloride → HCID 15952317, compound

HRID 502341Notes

Reaction equation

HRID 502341 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](Cl)=[O:24]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][CH:28]=[C:20]([CH3:19])[CH:21]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 743753-Methylbenzoyl chlorideHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 15952317HCID 15952317, compoundYield 56%

Procedure

The title compound (22 mg, 56%) was prepared analogously to example 7 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 3-methylbenzoyl chloride. MS:387.4 (MH+)

Sources & evidence

ORD record
ord-c8d43dfd1def468095cf21643e335b5b
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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