4-Chlorobenzoyl chloride → HCID 68459357, compound

HRID 502343Notes

Reaction equation

HRID 502343 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][C:20]([Cl:19])=[CH:21][CH:22]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68459357HCID 68459357, compoundYield 66%

Procedure

The title compound (27 mg, 66%) was prepared analogously to example 7 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 4-chlorobenzoyl chloride. MS: 407.4 (MH+).

Sources & evidence

ORD record
ord-5270e9c3578946abafec4973f8ce7dab
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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