1-Naphthalenecarbonyl chloride → HCID 68456371, compound

HRID 502349Notes

Reaction equation

HRID 502349 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[C:19]1([C:29](Cl)=[O:30])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:29]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][CH:20]=3)=[O:30])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 701461-Naphthalenecarbonyl chlorideHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68456371HCID 68456371, compoundYield 62%

Procedure

The title compound (26 mg, 62%) was prepared analogously to example 7 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 1-napthoyl chloride. MS: 423.4 (MH+).

Sources & evidence

ORD record
ord-7164935608cf47dd949e5c609c4d5b19
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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