6-Methylnicotinic acid → HCID 68458319, compound

HRID 502351Notes

Reaction equation

HRID 502351 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][N:21]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][C:20]([CH3:19])=[N:21][CH:22]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 1378606-Methylnicotinic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68458319HCID 68458319, compoundYield 8%

Procedure

The title compound (3 mg, 8%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 6-methylnicotinic acid. MS: 388.4 (MH+).

Sources & evidence

ORD record
ord-acdb8c7bf532450b8d0c2e8f8ae2e118
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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