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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502353Generated: October 26, 2026

4-Methyl-m-anisic acid → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-3-methoxy-4-methyl-benzamide

https://huagongshe.com/reaction/502353

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methyl-m-anisic acidHCID 81579—
Reactant1-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamineHCID 59210377—
ProductN-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-3-methoxy-4-methyl-benzamideHCID 6845603469%

Reaction Steps

The title compound (29 mg, 69%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 3-methoxy-4-methylbenzoic acid. MS: 417.4 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07772253B2
Source datasetuspto-grants-2010_08
ORD IDord-d2ffab2e225f4d08aa8714e137d4dd97
Source noteuspto-grants-2010_08