2,3-Dimethoxybenzoic acid → HCID 68456351, compound

HRID 502354Notes

Reaction equation

HRID 502354 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][O:20][C:21]1[C:29]([O:30][CH3:31])=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](O)=[O:24]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][CH:28]=[C:29]([O:30][CH3:31])[C:21]=3[O:20][CH3:19])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 152042,3-Dimethoxybenzoic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68456351HCID 68456351, compoundYield 14%

Procedure

The title compound (6 mg, 14%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 2,3-dimethoxy-benzoic acid. MS: 433.5 (MH+).

Sources & evidence

ORD record
ord-088bc3e4788d46f291a58e52775ac520
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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