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Borane;pyridine → N-(1-(4-chloro-3-ethoxybenzyl)piperidin-4-yl)-5-methylnicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Borane;pyridine | HCID 2723995 | — |
| 反応物 | 4-Chloro-3-ethoxybenzaldehyde | HCID 54775642 | — |
| 反応物 | 5-Methyl-N-(piperidin-4-yl)-nicotinamide | HCID 65562108 | — |
| 反応物 | 1h-Indole-7-carboxylic acid[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-amide | HCID 68456899 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | N-(1-(4-chloro-3-ethoxybenzyl)piperidin-4-yl)-5-methylnicotinamide | HCID 11963995 | 57% |
反応手順
To a solution of 5-methyl-N-(piperidin-4-yl)-nicotinamide (22 mg, 0.10 mmol), 4-chloro-3-ethoxy-benzaldehyde (22 mg, 0.12 mmol) in DCE:EtOH (1:11 mL) was added acetic acid (25 μL) and pyridine-borane complex (25 μL, 8M in pyridine, 0.2 mmol). The reaction was shaken for 16 h, after which time it was concentrated and purified by reversed phase HPLC (MeCN:H2O) affording the title compound (22 mg, 57%). MS: 388.4 (MH+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772253B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-9c544fc82ba740ae82223ec8cd956604 |
| 出典メモ | uspto-grants-2010_08 |