4-Amino-3,5-diethoxybenzaldehyde → N-[1-(4-Amino-3,5-diethoxy-benzyl)piperidin-4-yl]-5-methyl-nicotinamide

HRID 502361Notes

Reaction equation

HRID 502361 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:16]=1)[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:8].[NH2:17][C:18]1[C:25]([O:26][CH2:27][CH3:28])=[CH:24][C:21]([CH:22]=O)=[CH:20][C:19]=1[O:29][CH2:30][CH3:31]>>[NH2:17][C:18]1[C:19]([O:29][CH2:30][CH3:31])=[CH:20][C:21]([CH2:22][N:13]2[CH2:12][CH2:11][CH:10]([NH:9][C:7](=[O:8])[C:6]3[CH:16]=[C:2]([CH3:1])[CH:3]=[N:4][CH:5]=3)[CH2:15][CH2:14]2)=[CH:24][C:25]=1[O:26][CH2:27][CH3:28]

Participants

3

Reactant 2

HCID 591282764-Amino-3,5-diethoxybenzaldehydeHCID 655621085-Methyl-N-(piperidin-4-yl)-nicotinamide

Product 1

HCID 68458363N-[1-(4-Amino-3,5-diethoxy-benzyl)piperidin-4-yl]-5-methyl-nicotinamideYield 34%

Procedure

The title compound (14 mg, 34%) was prepared analogously to example 30 from 5-methyl-N-(piperidin-4-yl)-nicotinamide and 4-amino-3,5-diethoxybenzaldehyde. MS: 413.5 (MH+)

Sources & evidence

ORD record
ord-b775cdce2d7240f789f1f4bee4a1a4fb
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

Loading…