反应详情

To a solution of (3-amino-5-ethoxy-4-iodo-phenyl)-methanol (4.9 g, 16.72 mmol) in dichloromethane (100 mL) was added MnO2 (7.27 g, 83.59 mmol) and the reaction mixture heated to reflux for 3 h. Filtration through Hyflo, concentration by evaporation under reduced pressure and purification with column chromatography on silica eluting with hexane/ethyl acetate (3:1) yielded 3.14 g (60%) of the title compound.

1. temperaturethe reaction mixture heated
2. temperatureto reflux for 3 h
3. filtrationFiltration
4. concentrationthrough Hyflo, concentration
5. customby evaporation
6. customunder reduced pressure and purification with column chromatography on silica eluting with hexane/ethyl acetate (3:1)