3-Amino-5-ethoxy-4-iodo-benzaldehyde → N-[1-(5-Amino-3-ethoxy-4-iodo-benzyl)piperidin-4-yl]-5-methyl-nicotinamide

HRID 502370Notes

Reaction equation

HRID 502370 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:16]=1)[C:7]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:8].[NH2:17][C:18]1[C:19]([I:29])=[C:20]([O:26][CH2:27][CH3:28])[CH:21]=[C:22]([CH:25]=1)[CH:23]=O>>[NH2:17][C:18]1[C:19]([I:29])=[C:20]([O:26][CH2:27][CH3:28])[CH:21]=[C:22]([CH:25]=1)[CH2:23][N:13]1[CH2:12][CH2:11][CH:10]([NH:9][C:7](=[O:8])[C:6]2[CH:16]=[C:2]([CH3:1])[CH:3]=[N:4][CH:5]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 587063533-Amino-5-ethoxy-4-iodo-benzaldehydeHCID 655621085-Methyl-N-(piperidin-4-yl)-nicotinamide

Product 1

HCID 68457737N-[1-(5-Amino-3-ethoxy-4-iodo-benzyl)piperidin-4-yl]-5-methyl-nicotinamideYield 8%

Procedure

The title compound (4 mg, 8%) was prepared analogously to example 30 from 5-methyl-N-(piperidin-4-yl)-nicotinamide and 5-amino-3-ethoxy-4-iodo-benzaldehyde. MS: 495.4 (MH+).

Sources & evidence

ORD record
ord-36e3db163ba44fbc8d62e783a6f5a123
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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