Pyrimidine-5-carboxylic acid → HCID 68456978, compound

Participants

Reaction Steps

In analogy to the procedure described in example 50k), pyrimidine-5-carboxylic acid piperidin-4-ylamide [prepared in analogy to the procedures described in examples 50 h) and 50i) by condensation of pyrimidine-5-carboxylic acid with 4-amino-piperidine-carboxylic acid tert-butyl ester to give 4-[(pyrimidine-5-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester followed by Boc cleavage with trifluoroacetic acid] was reacted with 3,5-diethoxy-4-fluoro-benzaldehyde (example 50 g), sodium cyano-borohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light yellow solid. MS: 403.3 (MH+).

Provenance & Evidence