HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Pyrimidine-5-carboxylic acid[1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Ethoxy-4-methoxybenzaldehyde | HCID 244728 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Pyrimidine-5-carboxylic acid[1-(3,5-diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-amide | HCID 68454648 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Pyrimidine-5-carboxylic acid[1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-amide | HCID 68456362 | — |
Reaction Steps
In analogy to the procedure described in example 50k), pyrimidine-5-carboxylic acid piperidin-4-ylamide (example 56) was reacted with 3-ethoxy-4-methoxy-benzaldehyde, sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless solid. MS: 371.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772253B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-fe93eb431be4452e9ff298a45990645c |
| Source note | uspto-grants-2010_08 |