Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Pyrimidine-5-carboxylic acid[1-(3-ethoxy-4-fluoro-benzyl)-piperidin-4-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Fluoro-3-hydroxybenzoic acid | HCID 593635 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 3-Ethoxy-4-fluorobenzaldehyde | HCID 42614294 | — |
| 반응물 | 4-Chloro-3-ethoxybenzaldehyde | HCID 54775642 | — |
| 반응물 | Pyrimidine-5-carboxylic acid[1-(3,5-diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-amide | HCID 68454648 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Pyrimidine-5-carboxylic acid[1-(3-ethoxy-4-fluoro-benzyl)-piperidin-4-yl]-amide | HCID 68457813 | — |
반응 단계
In analogy to the procedure described in example 50k), pyrimidine-5-carboxylic acid piperidin-4-ylamide (example 56) was reacted with 3-ethoxy-4-fluoro-benzaldehyde [prepared from 3-hydroxy-4-fluoro-benzoic acid in analogy to the procedure described for the synthesis of 4-chloro-3-ethoxy-benzaldehyde in example 1a)], sodium cyano-borohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light yellow solid. MS: 359.1 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772253B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-94ac3a2707ed4a9e9267ee91e7f03bcc |
| 출처 메모 | uspto-grants-2010_08 |