HCID 68459332, compound → HCID 58706348, compound

Participants

Reaction Steps

The above prepared (2-ethoxy-4′-trifluoromethyl-biphenyl-4-yl)-methanol (0.359 g, 1.21 mmol) was dissolved in 12 ml of dichloromethane and treated with MnO2 (2.11 g, 20 eq.). After vigorous stirring for 8 h at ambient temperature, the reaction mixture was filtered over a pad of Celite, rinsed generously with dichloromethane, and evaporated to dryness to leave, after flash chromatography (silica gel, hexane/AcOEt=9/1) 0.372 g of the title aldehyde as yellow solid.

Provenance & Evidence