4-Fluorophenylboronic acid → 2,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde
Reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1I)[CH:7]=[O:8])[CH3:2].C(OC1C=C(C=C(OCC)C=1I)C=O)C1C=CC=CC=1.[F:36][C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[CH:39][CH:38]=1>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[O:8])[CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1[C:40]1[CH:41]=[CH:42][C:37]([F:36])=[CH:38][CH:39]=1)[CH3:2]Participants
4
Procedure
The necessary intermediate 2,6-Diethoxy-4′-fluoro-biphenyl-4-carbaldehyde was prepared as described in example 94, but reacting in the Suzuki coupling 3,5-diethoxy-4-iodo-benzaldehyde (CAS NO. 338454-05-0) instead of 3-benzyloxy-5-ethoxy-4-iodo-benzaldehyde with 4-fluorophenyl boronic acid, as light yellow solid.
Sources & evidence
- ORD record
- ord-a1b2e3603cf14c3b95a23d8325273585
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07772253B2
Reaction notes
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