4-Fluorophenylboronic acid → 2,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde

HRID 502412노트

반응식

HRID 502412 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1I)[CH:7]=[O:8])[CH3:2].C(OC1C=C(C=C(OCC)C=1I)C=O)C1C=CC=CC=1.[F:36][C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[CH:39][CH:38]=1>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[O:8])[CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1[C:40]1[CH:41]=[CH:42][C:37]([F:36])=[CH:38][CH:39]=1)[CH3:2]

참가 물질

4

반응물 3

HCID 2856454-Fluorophenylboronic acidHCID 22636808HCID 22636808, 화합물HCID 22636947HCID 22636947, 화합물

생성물 1

HCID 593831002,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde

실험 절차

The necessary intermediate 2,6-Diethoxy-4′-fluoro-biphenyl-4-carbaldehyde was prepared as described in example 94, but reacting in the Suzuki coupling 3,5-diethoxy-4-iodo-benzaldehyde (CAS NO. 338454-05-0) instead of 3-benzyloxy-5-ethoxy-4-iodo-benzaldehyde with 4-fluorophenyl boronic acid, as light yellow solid.

출처 및 근거

ORD 기록
ord-a1b2e3603cf14c3b95a23d8325273585
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07772253B2

반응 노트

불러오는 중…