Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-2,6-dimethyl-terephthalamic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 3,5-Diethoxy-4-fluoro-benzaldehyde | HCID 59128273 | — |
| 반응물 | 2,6-dimethyl-N-piperidin-4-yl-terephthalamic acid | HCID 68456914 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-2,6-dimethyl-terephthalamic acid | HCID 68454867 | — |
반응 단계
In analogy to the procedure described in example 50k), 2,6-dimethyl-N-piperidin-4-yl-terephthalamic acid (example 126b) was reacted with 3,5-diethoxy-4-fluoro-benzaldehyde (example 50 g), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless solid. MS: 472.9 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772253B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-37cac8a2be2f41948fd9beecf5e5ea7e |
| 출처 메모 | uspto-grants-2010_08 |