反应详情

The necessary intermediate 2,6-Diethoxy-4′-trifluoromethyl-biphenyl-4-carbaldehyde was prepared as described in example 94, but coupling in the Suzuki reaction 3,5-diethoxy-4-iodo-benzaldehyde instead of 3-benzyloxy-5-ethoxy-4-iodo-benzaldehyde with 4-trifluoromethyl-phenyl boronic acid instead of 4-fluorophenyl boronic acid, as white crystals.