4-(Trifluoromethyl)phenylboronic acid → HCID 86609555, compound

HRID 502425Notes

Reaction equation

HRID 502425 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1I)[CH:7]=[O:8])[CH3:2].[F:16][C:17]([F:28])([F:27])[C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[O:8])[CH:9]=[C:10]([O:13][CH2:14][CH3:15])[C:11]=1[C:21]1[CH:22]=[CH:23][C:18]([C:17]([F:28])([F:27])[F:16])=[CH:19][CH:20]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 226368083,5-Diethoxy-4-iodobenzaldehyde

Product 1

HCID 86609555HCID 86609555, compound

Procedure

The necessary intermediate 2,6-Diethoxy-4′-trifluoromethyl-biphenyl-4-carbaldehyde was prepared as described in example 94, but coupling in the Suzuki reaction 3,5-diethoxy-4-iodo-benzaldehyde instead of 3-benzyloxy-5-ethoxy-4-iodo-benzaldehyde with 4-trifluoromethyl-phenyl boronic acid instead of 4-fluorophenyl boronic acid, as white crystals.

Sources & evidence

ORD record
ord-04ee0c1da8d447d2ab501e8cf514d0e7
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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