Sodium Hydroxide → HCID 86609558, compound

Participants

Reaction Steps

The above prepared 3,5-bis-(2-fluoro-ethoxy)-benzoic acid methyl ester (1.45 g, 5.57 mmol) was dissolved in 19 ml of THF/ethanol=1/1 and treated with 9.3 ml of aq. NaOH (3M, 5 eq.). The mixture was stirred for 1.5 h at ambient temperature and was then poured onto crashed ice/AcOEt/HCl dil.; the organic layer was washed with water, dried over sodium sulfate, and evaporated to dryness to leave 1.36 g of the title compound as white solid.

Provenance & Evidence