Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Rac-n-[1-(4-chloro-3,5-diethoxy-benzyl)-piperidin-4-yl]-3-(2,3-dihydroxy-propoxy)-5-methoxy-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | N-[1-(4-Chloro-3,5-diethoxy-benzyl)-piperidin-4-yl]-3-hydroxymethyl-5-methoxy-benzamide 4-Chloro-3,5-diethoxy-benzoic acid ethyl ester | HCID 68456709 | — |
| 반응물 | rac-3-(2,3-dihydroxy-propoxy)-5-methoxy-N-piperidin-4-yl-benzamide hydrochloride | HCID 68459504 | — |
| 반응물 | HCID 131728279 | HCID 131728279 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Rac-n-[1-(4-chloro-3,5-diethoxy-benzyl)-piperidin-4-yl]-3-(2,3-dihydroxy-propoxy)-5-methoxy-benzamide | HCID 68455978 | — |
반응 단계
In analogy to the procedure described in example 50k), rac-3-(2,3-dihydroxy-propoxy)-5-methoxy-N-piperidin-4-yl-benzamide hydrochloride (prepared from rac-4-[3-(2,2-dimethyl-[dioxolan-4-ylmethoxy)-5-methoxy-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester (example 175a) by reaction with HCl/dioxane in EtOH in analogy to the procedure described in example 250b)] was reacted with 4-chloro-3,5-diethoxy-benzaldehyde (example 219), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light brown solid. MS: 537.4 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772253B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-1805e5d9ccf44c06b1a8d948d3ae816d |
| 출처 메모 | uspto-grants-2010_08 |