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Diisopropylethylamine → 3-Carbamoylmethoxy-N-[1-(2,6-diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-yl]-5-methoxy-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 2,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde | HCID 59383100 | — |
| 反応物 | HCID 68458066 | HCID 68458066 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-Carbamoylmethoxy-N-[1-(2,6-diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-yl]-5-methoxy-benzamide | HCID 68458292 | — |
反応手順
In analogy to the procedure described in example 50k), 3-carbamoylmethoxy-5-methoxy-N-piperidin-4-yl-benzamide hydrochloride (example 250b) was reacted with 2,6-diethoxy-4′-fluoro-biphenyl-4-carbaldehyde (example 102), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless solid. MS: 580.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772253B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-d3be4e956c91484cb8e568ebd509376a |
| 出典メモ | uspto-grants-2010_08 |