反应详情

can include, for example, dissolving the midazolam base produced in step (a) in a solvent or a solvent mixture, e.g., at elevated temperature; adding maleic acid, e.g., as a solution in a solvent, which can include an organic solvent, to produce midazolam maleate; allowing the solution to cool sufficiently to precipitate midazolam maleate (e.g., in the form of crystals); and collecting the precipitate, e.g., by filtration and, optionally, washing and/or drying the precipitate.