反应详情

Thiosulfuric acid S-[2-(1H-indol-3-yl)-ethyl]ester, O-sodium salt (5.04 g, 18 mmol) was suspended in 105 ml of 50% phosphoric acid and covered with a layer of 160 ml of ether. The mixture was refluxed for 6 hours. After cooling, the phases were separated and the aqueous phase was extracted with ether and the organic phases were concentrated to dryness by evaporation. The crude product was obtained in a yield of 3.2 g (100%).

1. temperatureThe mixture was refluxed for 6 hours
2. temperatureAfter cooling
3. customthe phases were separated
4. extractionthe aqueous phase was extracted with ether
5. concentrationthe organic phases were concentrated to dryness by evaporation