Morpholine → 2-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine

Participants

Reaction Steps

A mixture of 2,4-dichloro-thieno[3,2-d]pyrimidine (64), (8.68 g, 42.34 mmol), morpholine (8.11 mL, 2.2 eq.) and methanol (150 mL) was stirred at room temperature for 1 hour. The reaction mixture was then filtered, washed with water and methanol, to yield the title compound as a white solid (11.04 g, 100%).

Provenance & Evidence