HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Cyanophenyl)glycine → 1-Methyl-2-[n-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Cyanophenyl)glycine | HCID 817965 | — |
| Reactant | 3-Amino-4-methylaminobenzoic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide | HCID 18412538 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-2-[n-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide | HCID 18412557 | 24% |
Reaction Steps
Prepared analogously to Example 25c from N-(4-cyanophenyl)glycine and 3-amino-4-methylaminobenzoic acid-N-(2-pyridyl)-N-ethoxycarbonylmethylamide. Yield: 24% of theory; Rf value: 0.56 (silica gel; dichloromethane/methanol=4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-56cf75a9d0f340dda7254bf393c2a5f5 |
| Source note | uspto-grants-2004_03 |